There is a sequence of unlocking and remote start and relocking that can cause your remote to not unlock the doors. I remember m dealer explaining this but he didn't get int the details and frankly I didn't pay a ton of attention because I was playing with the radio.
BUT - he did say that if it happens to simply reprogram the remote through the DIC. here's the instructions from page 250 in the Yukon manual -
Relearn Remote Key
This display allows you to match remote keyless
entry transmitters to your vehicle. To match a
remote keyless entry transmitter to your vehicle,
do the following:
1. Press the vehicle information button until
PRESS V (the checkmark button) TO RELEARN REMOTE KEY
displays.
2. Press the set/reset button until REMOTE KEY
LEARNING ACTIVE is displayed.
3. Press and hold the lock and unlock buttons
on the first transmitter at the same time for
approximately 15 seconds.
A chime will sound indicating that the
transmitter is matched.
4. To match additional transmitters at this time,
repeat Step 3.
Each vehicle can have a maximum of eight
transmitters matched to it.
5. To exit the programming mode, you must
cycle the key to LOCK.
Hope that fixes it.