I'm not familiar with a 4L68e but if your comparing the 60e to the 80e, the main difference is through-put capability. A "built" 4L60e is only good for about 500 to 550 hp. There 3/4 clutch pack leaves a lot to be desired. The 4L80e is good for 500hp out of the box and can be built for 1,000 hp
The other big difference is in the gear ratio's. The 4L60e has a much deeper 1st gear. The 80e is more like a manual close ratio 4 speed.
Ratio's are 4L60e 1ST / 3.059 2ND / 1.625 3RD / 1.0 4TH .696 TO 1
................ 4l80e 1ST / 2.482 2ND / 1.482 3RD / 1.0 4TH .75 TO 1
I have the 4L80e in my Tahoe and I love it. I also have the TCI TCU control unit to take advantage of all the tricks it can do. I have the paddle shifter set up and also a trans brake. The taller first gear is no problem because I also have 4:56 gears.
I also have a "built" 4L60e in a Camaro that is handling 600 plus hp without a problem, yet. But, the Z can spin the wheels easier to get rid of excess power, where the Tahoe has a lot more weight holding that rubber to the ground.