I bought a Garmin Nuvi 750 a little while ago. Are you talking about the wire to the cig lighter and the headphone/AUX out wires?
I bought a vent mount so that I could put the Nuvi on the center stack and have it close to me. The windshield was too far away. A dash pad also works well. Since my trips are usually pretty short, I simply charge it inside the house with the USB and run on battery power in the Yukon. I put the power adapter away until I need it. When it is charging in the vehicle, I run the power cable along the right side of the steering column down to the power outlet. It doesn't get in the way at all.
For the AUX out, I don't like the way it sticks out of the Nuvi but again, I run the wire down the side of the steering column and down to the floor to connect it to the AUX plugs on our rear entertainment system. That way, there aren't wires criss-crossing across the dash.