Drop the lower radiator hose. I just did this on my Yukon. I replaced the thermostat. I think that they have pretty much kicked the possibility of air bubbles in these newer systems. I dropped the coolant, replaced the stat, replaced the hose, filled the tank until it was full and stopped draining down into the block. Then I ran the truck, got to normal temps, shut it down, let it cool, checked, topped off, and I haven't had an issue since.